Aluminium has a finite fatigue life, meaning eventually, regardless of the load it will eventually fail (crack). Greater load, sooner it will crack. Heck... it doesn't stop us making aircraft out of it though and running em' for 40 years. Or rims!
Ferrous materials don't have this finite fatigue life properties
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If you can find forged alum materials as opposed to extruded it will give you more strength (avoid cast if there is such a thing for alum beams available). You might not have anything other than extruded readily available when it comes channel.
The easy solution would be to have a steel trailer base for housing axles and hitch and alum frame for rest of the teardrop as the loading on this aluminium will be minimal, meaning it will last (or just use timber). Thats the 'no brainer' approach, but I believe there is still validity in using aluminium for a light trailer with a bit of engineering
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Alum is just over a quarter of the weight of steel per cc. Alum has a GREATER tensile strength till it yields then steel (AMAZING!), yield meaning deformation / elongation. however, it has a far lesser 'ultimate' tensile strength, so naturally would break sooner.
Some general alum alloy and steel properties to compare:
http://asm.matweb.com/search/SpecificMaterial.asp?bassnum=MA6061t6
http://asm.matweb.com/search/SpecificMaterial.asp?bassnum=MQ304A
Ways to reduce fatigue is simply load distribution, over engineering and dampening of shocks (so suspension, generous welding, gussets).
some more food for thought.